A detailed statistical analysis of the boron biodistribution dynamics was performed to find a ‘window of opportunity’ for BNCT. The data demonstrate variations in boron accumulation in different tissues depending on the compound used, as well as significant inter-animal variation. The protocol of administration of BPA and BSH compounds used did not allow achieving the parameters necessary for the successful course of BNCT in a glioma orthotopic xenograft mouse model. Therapy for malignant tumors in the human brain is rather challenging. Despite considerable efforts to develop new drugs and treatments, patients’ mean overall survival has increased by only three months (from 12 to 15 months). Their invasive nature and location in vital regions of the human brain make these types of tumors difficult for surgery however, adjuvant therapy does not provide the desired results. Therefore, the elaboration of targeted radiotherapy methods is a promising approach for brain tumor therapy. One such treatment option may be boron neutron capture therapy (BNCT).īNCT exploits the ability of the isotope 10B to capture thermal neutrons and produce 478 keV γ rays, 4He particles and 7Li recoil ions, the latter two have high-linear energy transfer properties and a high biological effectiveness relative to photons. The range of these particles in tissue is restricted from 4 to 8 µm, thus limiting their effects to one cell diameter.
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